Clinical Operationalization of the Cell Danger Response
A five-phase treatment protocol — outcomes in 100 patients with chronic post-exposure illness.
Research Library
Dr. Heyman's Papers
Dr. Heyman's BeyondMold full research monographs. View any of them in your browser, or download the PDF.
CDR3 as Chronobiological Restoration
Rebuilding Oscillatory Reserve in the Stalled Cell Danger Response — and the Brain as the Conductor of Recovery
CIRS & the Cell Danger Response
An Evidence Review — Comparative Assessment of Evidence Quality, Journal Prestige, and Academic Acceptance
Clinical Framework: The Cell Danger Response in Chronic Mold Illness
Mechanism, staging, and a phenotype-matched, sequence-gated protocol
Counting Is Not Clustering
Provenance, Derivation, and Psychometric Validity of the CIRS Symptom-Cluster Diagnostic Model
From Haplotype to Healing Cycle
A Cell Danger Response Counter-Model of Individual Vulnerability in Biotoxin-Associated Illness
From Transcriptomics to Mitochondrial Energetics
Why Gene-Expression Panels Are a Confounded Proxy — and the Seahorse Assay a Direct Measure of Mitochondrial Function
Healing the Mold Within: The Companion Edition
A Plain-Language Guide to the New Science of Mold Illness
Phenotype A: The Stuck Alarm
Quieting an active CDR1 danger signal — the anti-inflammatory, pro-resolution, mast-cell, and barrier agents that turn the alarm down
Phenotype B: The Drained Battery
Rebuilding the mitochondrial engine — ETC support, NAD+ and redox restoration, substrate and cofactors, on a foundation of strict pacing
Phenotype C: The Worn out Defender
Reconstituting an exhausted immune system while rebuilding the engine — thymic peptides, plant sterols, antiviral support, and cofactor repletion
Phenotype D: The Closed Gate
Opening the Gate — a neuroendocrine & integrated-stress-response treatment roadmap
Position Paper: Beyond CIRS
The Cell Danger Response as a Unifying Framework — and the Case for Direct Measurement over Transcriptomic Inference
Precision Versus the Average
How a one-size protocol and an omics-guided, terrain-matched model of the Cell Danger Response diverge — read through the lens of Number Needed to Treat
Reclassifying the CIRS Panel Through the Cell Danger Response
Expanded Edition — the panel as a gated, conditional staging instrument, not a flat count
The Architecture of Reserve
Load over reserve, the self-degrading alarm, and the gated return to sanctuary, reserve, safety, and resiliency
The Sentinel Mucosa
The Nasal Microbiome as a Site of Lost Immune Tolerance — and the Case for Retiring MARCoNS-Directed Therapy
The Tolerance Threshold
Loss of tolerance as the unifying logic of the stuck alarm — barrier integrity, measurement, and the restoration of innate calm
